Essay --

Introduction Cancer is a wide-ranging group of diseases engenderd by anarchical cell growth that more than 200 different types have been identified. In this disease, the cells divide and grow intensity, forming malignant tumors, and invading nearby parts of the body(1).Cancer has been in the whole of human history. The oldest written record dates back to about 1600 years BC in Egypt described breast cancer(2). The cause of cancer is complex and part unknown. Although only 5-10% of cancers are due to inherited gene defects, tobacco, poor diet, certain infections, treated with radiation, lack of physical activity, obesity and pollution can directly ill-treat genes and ultimately lead to carcinogenic mutations (3).Rendering to recent statistics, cancer is responsible for 23% of all deaths in USA and is the second most common cause of death after heart disease (4). It is expected that by 2020 the world population reaches 7.5 billion that 15 million new cases diagnosed and 12 million patients provide lose their lives (5). Based on figures provided in 2013 by the American Cancer Society, the most common cancer in wo custody is breast cancer (29%) and in men is prostate cancer (28%) (6).Surgery as a primary method in treatment of solid cancers involved in pain relief and patients survival. In surgery the tumor was completely removed along with the lymph nodes in the area. This method is the only way to eliminate some cases of cancer (7). Other intrusive processes that usually used are radiation and chemotherapy with the aim of killing the cancerous cells. Because they grow and divide faster than healthy cells so they are sensitive to chemotherapeutic and radiation agents(8).Regarding that the efficiency of a method directly depends on its ab... ...sed to form silica xerogels loaded with drugs, so a changing production conditions(as the ratio of reagents, temperature and concentration of gas may alter the properties of xerogels(14).In comparison, mesoporous s ilica nanoparticles (MSN) form into homogenous structure with higher surface area that is favorable for adsorption of therapeutic drugs(41). MSN particles possess the susceptibility to load large and small molecules, adsorption of DNA and gene transfering(14). A transformation of drugs including antibiotics(42), anticancer drugs(41) and heart disease drugs(43) are loaded into mesoporous silica nanoparticles by chemichal or physical adsorption mechanism(41).Through the work of various research groups, it has been shown that silica particles are biocompatible and have a great potential for a variety of diagnostic and therapeutic applications, but recent studied